Ahead of the 2021 season, the Seattle Sounders hold the best record in MLS since entering the league in 2009. With 636 points from a record of 182-116-90, the Sounders have been a consistently dominant force for over a decade.
Here is a rundown of the team’s record against each opponent in MLS during the regular season:
| Atlanta United FC | |
| Chicago Fire | |
| Chivas USA | |
| FC Cincinnati | |
| Colorado Rapids | |
| Columbus Crew SC | |
| D.C. United | |
| FC Dallas | |
| Houston | |
| Inter Miami | |
| LAFC | |
| LA Galaxy | |
| Minnesota United | |
| Montreal Impact | |
| Nashville SC | |
| New England Revolution | |
| New York Red Bulls | |
| New York City FC | |
| Orlando City SC | |
| Philadelphia Union | |
| Portland Timbers | |
| Real Salt Lake | |
| San Jose Earthquakes | |
| Sporting KC | |
| Toronto FC | |
| Vancouver Whitecaps FC | |
| TOTAL | |
| no longer in MLS |
NOTES:
- Most Wins: Colorado Rapids, 18
- Most Losses: Real Salt Lake, 12
- Fewest Wins (minimum five matches): Montreal Impact, 2
- Fewest Losses (minimum five matches): Minnesota United, 0
- Home Record: 118-38-39 (335 goals for, 172 goals allowed)
- Road Record: 64-78-51 (240 goals for, 279 goals allowed)
- First Half: 254 goals for, 203 goals allowed
- Second Half: 325 goals for, 250 goals allowed
